Current Issue : January - March Volume : 2021 Issue Number : 1 Articles : 5 Articles
Background: Volatile anesthetic agents used during surgery have immunomodulatory effects which could affect\npostoperative outcomes. Recognizing that regulatory T cells (Tregs) plays crucial roles in transplant tolerance and high\nperipheral blood Tregs associated with stable kidney graft function, knowing which volatile anesthetic agents can induce\nperipheral blood Tregs increment would have clinical implications. This study aimed to compare effects of desflurane and\nsevoflurane anesthesia on peripheral blood Tregs induction in patients undergoing living donor kidney transplantation.\nMethods: A prospective, randomized, double-blind trial in living donor kidney transplant recipients was conducted at a\nsingle center, tertiary-care, academic university hospital in Thailand during August 2015 - June 2017. Sixty-six patients\nwere assessed for eligibility.......................................
Uterus transplantation (UTx) can provide a route to motherhood for women with\nMayer-Rokitansky-Kuster-Hauser syndrome (MRKHS), a congenital disorder characterized by\nuterovaginal aplasia, but with functional ovaries. Based on our four successful living-donor\ntransplantations and two resulting births, this analysis presents parameters relevant to standardizing\nrecipient/donor selection, UTx surgery, and postoperative treatment, and their implementation in\nroutine settings. We descriptively analyzed prospectively collected observational data from our\nfour uterus recipients, all with MRKHS, their living donors, and the two newborns born to two\nrecipients, including 1-year postnatal follow-ups. Analysis included only living-donor/recipient\npairs with completed donor/recipient surgery. Two recipients, both requiring ovarian restimulation\nunder immunosuppression after missed pregnancy loss in one case and no pregnancy in the\nother, each delivered a healthy boy by cesarean section. We conclude that parameters crucial to\nsuccessful transplantation, pregnancy, and childbirth include careful selection of donor/recipient\npairs, donor organ quality, meticulous surgical technique, a multidisciplinary team approach,\nand comprehensive follow-up. Surgery duration and blood vessel selection await further optimization,\nas do the..........................
Background: Autologous hematopoietic stem cell transplantation (aHSCT) is a treatment option for a selected\ngroup of systemic sclerosis (SSc) patients with good available evidence but can be associated with considerable\nmorbidity and mortality. The aim of this study was to describe infectious complications and distinct immune\nreconstitution patterns after aHSCT and to detect risk factors in lymphocyte subsets, which are associated with an\nelevated rate of infections after aHSCT.\nMethods: Seventeen patients with SSc were included in this single-center retrospective cohort study. Clinical and\nlaboratory data was collected before and for 12 months after aHSCT, including immunophenotyping of peripheral\nwhole blood by fluorescence-activated cell sorting.............................
Introduction. Nowadays, minimally invasive surgery in kidney transplantation is a reality thanks to robotic assistance. In this\npaper, we describe our experience, how we developed the robotic assisted Kidney transplantation (RAKT) technique, and\nanalyze our results. Material and Methods. This is a retrospective study of all RAKTs performed at our center between July\n2015 and March 2020. We describe the donor selection, surgical technique, and analyze the surgical results and complications.\nA comparison between the first 20 cases and the following ones is performed. Results. During the aforementioned period, 82\nliving donor RAKTs were performed..................................
Background. Frailty contributes to increased morbidity and mortality in patients referred for and undergoing lung transplantation\n(LTX). The study aim was to determine if frailty is reversible after LTX in those classified as frail at LTX evaluation. Methods.\nConsecutive LTX recipients were included. All patients underwent modified physical frailty assessment during LTX evaluation.\nFor patients...........................
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